A Low-dose Of Atropine: Prevention For Myopia

Myopia, or nearsightedness, is a refractive error, which means that the eye does not bend or refract light properly to a single focus to see images clearly. In myopia, close objects look clear but distant objects appear blurred. It is often inherited and is discovered in children when they are between the age of 8 and 12 years old. During the teenage years, when the body grows rapidly, myopia may become worse.

myopia prevention

Accoding to the study “Five-Year Clinical Trial on Atropine for the Treatment of Myopia 2.” A total of 400 children were randomized to receive atropine 0.5%, 0.1%, or 0.01% once daily in both eyes in a 2:2:1 ratio.

There was a dose-related response in phase 1 with a greater effect in higher doses, but an inverse dose-related increase in myopia during phase 2 (washout), resulting in atropine 0.01% being most effective in reducing myopia progression at 3 years. Over 5 years it was observed, atropine 0.01% eye drops were more effective in slowing myopia progression with less visual side effects compared with higher doses of atropine.

What is Atopine?

Atropine occurs naturally in the deadly nightshade plant (Atropa belladonna) along with hyoscyamine. This plant has brown-purple flowers and berries which change from red to purple as the summer progresses

For medical use, it is refined and concentrated. It already has several uses in eye care, such as dilating the pupil and treating lazy eye. The effectiveness of a low dose (0.01 percent concentration) on childhood myopia was discovered almost accidentally by researchers who were studying side effects of larger doses.


In the view of ophthalmologists a tiny bit of atropine binds to certain growth receptors in the eyes, blocking stimulation that prompts the condition.

Additional advice: Get your kids outside in the daylight on a regular basis.

In addition, if your child has myopia or if you suspect a problem with his or her far vision, it’s important to get an exam by a pediatric ophthalmologist, and ask about low-dose atropine.

Application Instructions For Eye Drops:
  • Take out contact lenses before using this drug. Lenses may be put back in 15 minutes after this drug is given. Do not put contacts back in if your eyes are irritated or infected.
  • Do not touch the container tip to the eye, lid, or other skin.
  • Tilt your head back and drop drug into the eye.
  • After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.
  • Space each eye drug by 5 minutes.


The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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